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Skin Cancer
Despite significant increases in the numbers
of people surviving cancer, there yet exists a vastrift in the number who die
each year despite treatment. It remains one of the most challenging
diseases to treat, in part, due to the heterogeneity of the malady.
Most cancers originate as a single cell, and
thus monoclonal in origin, however, due to innate genetic instability of
subsequent cell generations, new characteristics create a heterogenic disease
well-defined by genetic clonal expansion epigenetic changes favoring phenotypic
diversity.
However,
cancer cells are not the only contributors to tumor heterogeneity. There exists
a reciprocal and dynamic interaction between the microenvironment constituents,
such as infiltrating cells, andjuxtapositoned matrices and cells to produce a
distinct tumor phenotype.
The
clinical relevance is that this tumorheterogeneity contributes significantly to
the efficacy of drug therapy and therefore imparts considerable
inter-individual variation in pharmacotherapy and clinical response to a myriad
of medications. Thus, this divergence underscores
the necessity to personalize therapeutic
regimens.
The world wide skin cancer day was celebrated
in the month of May. Many awareness programmes are undertaken to avoid skin
cancer. These mainly occur due to the excess use of more chemical products to
the skin and these spread to other body parts like arms, legs, nose and other
prominent organs of the body .
Many treatments are there for the skin cancer
there are Mohs Micrographic Surgery, Excisional Surgery, Electro surgery,
Cryosurgery, Radiation, Photodynamic Therapy, Laser Surgery, Topical
Medications. etc, Some will go with ayurvedic and homeopathy medicines which
will cure but time will taken and should be used for lifelong time
The above Article originally got published at
SciFed Oncology and Cancer Research Journal in 2017, to have a glance please
visit: Click Here
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